|Degree||PhD, 2003, Neuroscience/Neurophysiology, Keio University School of Medicine, Tokyo, Japan|
|Website||BIRC | brainLENS | UC-Stanford Precision Learning Center | twitter | Haskins|
|Research Interests||Brain development, Neuroimaging, Individual differences, Literacy acquisition, Dyslexia|
|Research Synopsis||Fumiko Hoeft MD PhD is Professor of Psychological Sciences, Director of Brain Imaging Research Center (BIRC) at UCONN, and Director of Laboratory for Learning Engineering and Neural Systems (brainLENS.org) located at UCONN/UCSF. She also has appointments as Professor of Psychiatry at UCONN Health, Senior Scientist & Senior Advisor of Strategic Planning at Haskins Laboratories, Co-Director of Haskins L2 (Language & Literacy) Global Innovation Hub, Adjunct Professor of UCSF Psychiatry, Weill Institute for Neurosciences and Dyslexia Center, and Adjunct Faculty at Keio Univ SoM Psychiatry.
Hoeft is a neurophysiologist, as well as a systems and developmental cognitive neuroscientist with theoretical interests in the neurobiological mechanisms underlying individual differences in brain maturational processes, acquisition of skills such as literacy and how they interact. She is also interested in identifying how biology (gene) and environment influence neurodevelopment. In her research, her lab employs a variety of neuroimaging techniques (e.g. fMRI, T1 aMRI, DWI, MRS, NIRS, EEG/MEG, TMS/tDCS), analytical approaches (e.g. machine learning, graph theory), designs (e.g. intergenerational neuroimaging, imaging genetics, human natural cross-fostering design), and perturbation techniques (e.g. neuromodulation using TMS/tDCS, perturbation of English literacy acquisition through foreign language/literacy learning, and atypical populations such as dyslexia). Hoeft received pre/postdoctoral research training at Harvard, UCLA, Caltech and Stanford.
Recent honors include awards from the International Dyslexia Association (IDA; 2014), Learning & the Brain Foundation (2015), University of California Office of the President (2016), Int’l Mind Brain & Education Society (IMBES; 2018), and Society for Neuroscience (SfN; 2018). She has published over 130 articles, reviews, and book chapters, and has delivered over 160 keynotes, talks and workshops at venues such as local schools, International conferences, TEDx and the White House. Her work has been widely covered in media such as The New York Times, NPR, CNN, the New Yorker, and Scientific American. She also serves on many boards at organizations such as the International Dyslexia Association (IDA) and National Center for Learning Disabilities (NCLD), and Bay Area Discovery Museum’s (BADM) Center for Childhood Creativity (CCC).
|Representative Publications||Malins JG, Pugh KR, Buis B, Frost SJ, Hoeft F, Landi N, Mencl WE, Kurian A, Staples R, Molfese PJ, Sevcik R, Morris R. Individual differences in reading skill are related to trial-by-trial neural activation variability in the reading network. J Neurosci 2018;38(12):2981-2989. PMID: 29440534. PMCID: PMC5864150 [Available on 2018-09-21] Evaluated: F1000 Neuroscience
Hancock R, Pugh KR, Hoeft F. The neural noise hypothesis of developmental dyslexia. Trends Cogn Sci (TiCS) 2017;21(6):434-448. PMID: 28400089; PMCID: PMC548955
Hancock R, Pugh KR, Hoeft F. Neural Noise Hypothesis of Developmental Dyslexia: (Trends in Cognitive Sciences 21, 434-448, 2017). Trends Cogn Sci (TiCS) 2017;21(11):909. PMID: 28869186. PMCID: PMC5724971
Hancock R, Richlan F, Hoeft F. Possible roles for frontostriatal circuits in reading disorder. Neurosci Biobehav Rev 2017;72:243-260. PMID: 27826071; PMCID: PMC5189679
Ho TC, Sanders SJ, Gotlib IH, Hoeft F. Intergenerational Neuroimaging of Human Brain Circuitry. Trends Neuroscience (TiNS). 2016;39(10):644-648. PMID: 27623194; PMCID: PMC5067069
Hancock R, Gabrieli JDE, Hoeft F. Shared temporoparietal dysfunction in dyslexia and typical readers with discrepantly high IQ. Trends Neurosci Educ 2016;5(4):173-177. PMID: 28439565; PMCID: PMC5400289
Haft SL, Myers CA, Hoeft F. Socio-emotional and cognitive resilience in children with reading disabilities. Curr Opin Behav Sci 2016;10:133-141. PMID:27747263; PMCID: PMC5058360
Vandermosten M, Hoeft F, Norton ES. Integrating MRI brain imaging studies of pre-reading children with current theories of developmental dyslexia: A review and quantitative meta-analysis. Curr Opin Behav Sci 2016;10:155-161. PMID: 27458603; PMCID: PMC4957935
Yamagata B, Black JM, Gimenez P, Mimura M, Yang TT, Reiss AL, Hoeft F. Sex-specific intergenerational transmission patterns in the human corticolimbic system. J Neurosci 2016;36(4):1254-60. PMID: 26818513; PMCID: PMC4728726. Press release: UCSF; Covered by: Scientific American
Rueckl JG, Paz-Alonso PM, Molfese PJ, Kuod W-J, Bick A, Frost SJ, Hancock R, Wu DH, Mencl WE, Duñabeitia JA, Lee J-R, Oliver M, Zevin JD, Hoeft F, Carreiras M, Tzeng OJ-L, Pugh KR, Frost R. A universal brain signature of proficient reading: Evidence from four contrasting languages. Proc Natl Acad Sci U S A (PNAS) 2015 Dec 15;112(50):15510-5. doi: 10.1073/pnas.1509321112. Epub 2015 Nov 30. PMID: 26621710; PMCID: PMC4687557
Myers CA, Vandermosten M, Farris EA, Hancock R, Gimenez P, Black JM, Casto B, Drahos M, Tumber M, Hendren RL, Hulme C, Hoeft F. White matter morphometric changes uniquely predict children’s reading acquisition. Psychol Sci 2014 Oct;25(10):1870-83. doi: 10.1177/0956797614544511. Epub 2014 Sep 11. PMID: 25212581; PMCID: PMC4326021 Press release: UCSF; Podcast: UCSF, NIH
Pugh KR, Frost SJ, Rothman DL, Hoeft F, Del Tufo SN, Mason GF, Molfese PJ, Mencl WE, Grigorenko EL, Landi N, Preston JL, Jacobsen L, Seidenberg MS, Fulbright RK. Glutamate and choline levels predict individual differences in reading ability in emergent readers. J Neurosci 2014 Mar 12;34(11):4082-9. doi: 10.1523/JNEUROSCI.3907-13.2014. PMID: 24623786; PMCID: PMC3951703 Press release: Yale, NICHD
Hong DS, Hoeft F, Marzelli MJ, Lepage JF, Roeltgen D, Ross J, Reiss AL. Influence of the X-chromosome on neuroanatomy: evidence from Turner and Klinefelter syndromes. J Neurosci 2014 Mar 5;34(10):3509-16. doi: 10.1523/JNEUROSCI.2790-13.2014. PMID: 24599451; PMCID: PMC3942570
Kesler SR, Wefel JS, Hosseini SM, Cheung M, Watson CL, Hoeft F. Default mode network connectivity distinguishes chemotherapy-treated breast cancer survivors from controls. Proc Natl Acad Sci U S A (PNAS) 2013 Jul 9;110(28):11600-5. doi: 10.1073/pnas.1214551110. Epub 2013 Jun 24. PMID: 23798392; PMCID: PMC3710809
Hoeft F, Gabrieli JD, Whitfield-Gabrieli S, Haas BW, Bammer R, Menon V, Spiegel D. Functional brain basis of hypnotizability. JAMA Psychiatry 2012 Oct;69(10):1064-72. doi: 10.1001/archgenpsychiatry.2011.2190. Erratum in: JAMA Psychiatry 2013 Jan;70(1):97. PMID: 23026956; PMCID: PMC4365296. Press release: NICHD, Stanford; Author ITV in: Arch Gen Psychiatry
Hosseini SM, Hoeft F, Kesler SR. GAT: a graph-theoretical analysis toolbox for analyzing between-group differences in large-scale structural and functional brain networks. PLoS One 2012;7(7):e40709. doi: 10.1371/journal.pone.0040709. Epub 2012 Jul 13. PMID: 22808240; PMCID: PMC3396592
**Tanaka H, **Black JM, Hulme C, Stanley LM, Kesler SR, Whitfield-Gabrieli S, Reiss AL, Gabrieli JD, Hoeft F. The brain basis of the phonological deficit in dyslexia is independent of IQ. Psychol Sci 2011 Nov;22(11):1442-51. doi: 10.1177/0956797611419521. Epub 2011 Oct 17. PMID: 22006060. PMCID: PMC4380286 Press release: NICHD, Psychol Sci, Stanford & MIT **Shared 1st
Bryant DM, Hoeft F, Lai S, Lackey J, Roeltgen D, Ross J, Reiss AL. Neuroanatomical phenotype of Klinefelter syndrome in childhood: a voxel-based morphometry study. J Neurosci 2011 May 4;31(18):6654-60. doi: 10.1523/JNEUROSCI.5899-10.2011. PMID: 21543594; PMCID: PMC3148194
Hoeft F, McCandliss BD, Black JM, Gantman A, Zakerani N, Hulme C, Lyytinen H, Whitfield-Gabrieli S, Glover GH, Reiss AL, Gabrieli JD. Neural systems predicting long-term outcome in dyslexia. Proc Natl Acad Sci U S A (PNAS) 2011 Jan 4;108(1):361-6. doi: 10.1073/pnas.1008950108. Epub 2010 Dec 20. PMID: 21173250; PMCID: PMC3017159 Press release: NICHD, Stanford, MIT, & Vanderbilt; Covered by: Science
Hoeft F, Walter E, Lightbody AA, Hazlett HC, Chang C, Piven J, Reiss AL. Neuroanatomical differences in toddler boys with fragile x syndrome and idiopathic autism. JAMA Psychiatry 2011 Mar;68(3):295-305. doi: 10.1001/archgenpsychiatry.2010.153. Epub 2010 Nov 1. PMID: 21041609. PMCID: PMC4369209 Comment in: Arch Gen Psychiatry. 2011 Mar;68(3):230-1
Hoeft F, Carter JC, Lightbody AA, Cody Hazlett H, Piven J, Reiss AL. Region-specific alterations in brain development in one- to three-year-old boys with fragile X syndrome. Proc Natl Acad Sci U S A (PNAS) 2010 May 18;107(20):9335-9. doi: 10.1073/pnas.1002762107. Epub 2010 May 3. PMID: 20439717; PMCID: PMC2889103. Press release: NIMH & Stanford
Etkin A, Prater KE, Hoeft F, Menon V, Schatzberg AF. Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder. Am J Psychiatry 2010 May;167(5):545-54. doi: 10.1176/appi.ajp.2009.09070931. Epub 2010 Feb 1. PMID: 20123913. PMCID: PMC4367202 Comment in: Am J Psychiatry. 2010 May;167(5):489-92
Bray S, Chang C, Hoeft F. Applications of multivariate pattern classification analyses in developmental neuroimaging of healthy and clinical populations. Front Hum Neurosci 2009 Oct 23;3:32. doi: 10.3389/neuro.09.032.2009. eCollection 2009. PMID: 19893761; PMCID: PMC2773173
Haas BW, Mills D, Yam A, Hoeft F, Bellugi U, Reiss A. Genetic influences on sociability: heightened amygdala reactivity and event-related responses to positive social stimuli in Williams syndrome. J Neurosci 2009 Jan 28;29(4):1132-9. doi: 10.1523/JNEUROSCI.5324-08.2009. PMID: 19176822; PMCID: PMC2754840.
Hoeft F, Lightbody AA, Hazlett HC, Patnaik S, Piven J, Reiss AL. Morphometric spatial patterns differentiating boys with fragile X syndrome, typically developing boys, and developmentally delayed boys aged 1 to 3 years. JAMA Psychiatry 2008 Sep;65(9):1087-97. doi: 10.1001/archpsyc.65.9.1087. PMID: 18762595; PMCID: PMC2864400 Press release: Stanford
Watson C, Hoeft F, Garrett AS, Hall SS, Reiss AL. Aberrant brain activation during gaze processing in boys with fragile X syndrome. JAMA Psychiatry 2008 Nov;65(11):1315-23. doi: 10.1001/archpsyc.65.11.1315. PMID: 18981343.
Hoeft F, Wu DA, Hernandez A, Glover GH, Shimojo S. Electronically switchable sham transcranial magnetic stimulation (TMS) system. PLoS One 2008 Apr 9;3(4):e1923. doi: 10.1371/journal.pone.0001923. PMID: 18398456; PMCID: PMC2271126
Hoeft F, Barnea-Goraly N, Haas BW, Golarai G, Ng D, Mills D, Korenberg J, Bellugi U, Galaburda A, Reiss AL. More is not always better: increased fractional anisotropy of superior longitudinal fasciculus associated with poor visuospatial abilities in Williams syndrome. J Neurosci 2007 Oct 31;27(44):11960-5. PMID: 17978036
Hoeft F, Meyler A, Hernandez A, Juel C, Taylor-Hill H, Martindale JL, McMillon G, Kolchugina G, Black JM, Faizi A, Deutsch GK, Siok WT, Reiss AL, Whitfield-Gabrieli S, Gabrieli JD. Functional and morphometric brain dissociation between dyslexia and reading ability. Proc Natl Acad Sci U S A (PNAS) 2007 Mar 6;104(10):4234-9. Epub 2007 Feb 23. PMID: 17360506; PMCID: PMC1820738
Hoeft F, Hernandez A, McMillon G, Taylor-Hill H, Martindale JL, Meyler A, Keller TA, Siok WT, Deutsch GK, Just MA, Whitfield-Gabrieli S, Gabrieli JD. Neural basis of dyslexia: a comparison between dyslexic and nondyslexic children equated for reading ability. J Neurosci 2006 Oct 18;26(42):10700-8. PMID: 17050709 Evaluated: F1000 Biology
deCharms RC, Maeda(Hoeft) F, Glover GH, Ludlow D, Pauly JM, Soneji, D.J., Gabrieli, J.D.E., and Mackey, S.C. Control over brain activation and pain learned by using real-time functional MRI. Proc Natl Acad Sci USA (PNAS) 2005; 102(51): 18626-18631. Evaluated: F1000 Biology. Coverage: Nature, Nat Rev Neurosci
Maeda(Hoeft) F, Kanai R, Shimojo S. Changing pitch induced visual motion illusion. Curr Biol 2004; 14(23):R990-R991.
Maeda(Hoeft) F, Gangitano M, Thall M, Pascual-Leone A. Inter- and intra-individual variability of paired-pulse curves with transcranial magnetic stimulation (TMS). Clin Neurophysiol 2002;113:376-382
Maeda(Hoeft) F, Keenan J, Tormos JM, Topka H, Pascual-Leone A. Interindividual variability of the modulatory effect of repetitive transcranial magnetic stimulation on cortico-spinal excitability. Exp Brain Res 2000; 133:425-30
Maeda(Hoeft) F, Keenan J, Tormos JM, Topka H, Pascual-Leone A. Modulation of cortico-spinal excitability by repetitive transcranial magnetic stimulation. Clin Neurophysiol 2000;111: 800-805
|Career Highlights||Associate Director & Visiting Associate Professor of Stanford Univ Center for Interdisciplinary Brain Sciences Research (2008-2013); Associate/Full Professor of Psychiatry & Weill Institute for Neurosciences at UCSF (2012-2018); Co-Founder & Deputy Director of UCSF Dyslexia Center (2012-2018); Founder & Executive Director of UC6-Stanford Multi-University Precision Learning Center (2017-2018).|
NIH R01HD094834 (Multi-PIs Hoeft/UConn Hancock) 02/01/2019 – 01/31/2024
Intergenerational neuroimaging of language and reading networks using a natural cross-fostering design
$4,008,673 Total Cost
Goal: To dissociate the genetic, prenatal and postnatal experience on sex-specific transmission patterns of language and reading endophenotypes.
Role: PI (4th percentile)
Jacobs Fndtn Advanced Research Fellowship (PI Hoeft) 01/01/2019 – 12/31/2021
Nature and nurture of early reading skills
~$416,827 Total Cost (400,000 CHF)
Goal: To examine the extent to which environmental and genetic factors contribute to reading-related cognitive and neurobiological processes, and to develop a culturally-sensitive preliminary screener to identify at-risk children and a prevention program.
Role: PI (final stage interview completed)
NIH R01HD096261 (PI Hoeft) 09/15/2018 – 06/30/2023
Neural mechanisms underlying compensation in dyslexia.
$3,467,648 Total Cost
Goal: To understand the neurocognitive mechanisms underlying compensation in RD adults using a combination of measures of experimental neuromodulation, neurochemistry and neural activity/connectivity.
Anonymous Fndtn 2018-188563 (PI Uncapher) 09/01/2018 – 02/28/2021
$2,900,000 Total Cost
Development and validation of precision learning executive function (PLEF) tool
Goal: To develop, integrate, and validate cognitive assessment tools.
NIH R01HD086168 (Multi-PIs Haskins Pugh/Hoeft) 08/01/2016 – 06/30/2021
$3,162,696 Total Cost
Neurochemistry as a moderator of brain networks for reading
Goal: To test the neural noise hypothesis of dyslexia by examining relationships between neurochemistry, neural oscillation, functional activation, and functional connectivity and how these may predict individual differences in reading skills in children.
NIH R01HD078351 (PI Hoeft) 09/01/2015 – 06/30/2020
$2,971,534 Total Cost
Understanding literacy acquisition through immersion in foreign languages
Goal: To examine neurobiological, language and cognitive profiles as children learn a second language.
UCOP MRP-17-454926 (PI Hoeft) 01/01/2017 – 12/31/2019
UC Office of the President Multicampus Research Program & Initiatives Award
$577,751 Total Cost
Science-Based Innovation in Learning Center (SIL Center; now, Precision Learning Center)
Goal: The long-term goal is for the proposed Univ of CA center integrating efforts from 6 UC campuses is to be a national leader in ‘Precision Ed-Health’, and tackle issues associated with education and health disparity in underrepresented populations, with an initial emphasis on early identification and intervention of children at risk for learning challenges.
Oak Fndtn ORIO-16-012 (PI Hoeft) 09/01/2016 – 08/31/2019
$350,000 Total Cost
Assessing the impact of mentoring on students with learning differences
Goal: To examine individual differences in factors of LD middle-school children as well as programmatic factors that make one responsive to mentoring.
NSF 1540854 SL-CN (PI UCSF/Gazzaley) 09/30/2015 – 09/29/2018
$750,000 Total Cost
Science of Learning – Collaborative Network: Contributions of executive function subdomains to mathematical cognition and reading in the classroom: Assessment and training
Goal: To elucidate how multiple domains of executive functions (EFs) contribute to differences in math and reading in middle childhood.
NIH P50HD052120 (PI Florida State U/Wagner) 10/01/2017 – 06/30/2019
~$60,000 Total Cost
The Florida Learning Disabilities Research Center
The goal of this proposal is to develop multivariate models of various reading-related learning disabilities including neurobiological information.
Role: Co-I, PI of subcontract
NIH R15HD086662 (PI U Denver/McGrath) 09/22/2016 – 09/21/2019
Cognitive and neural predictors of comorbidity between reading and attention problems
Goal: This proposal adopts a multiple deficit framework to identify cognitive and neural predictors of the relationship (or covariance) between RD and ADHD, rather than the more common approach of predicting the individual disorders using two large population-based pediatric datasets of children 6-18 years.
NIH R37HD090153 (PI Haskins/Pugh) 07/01/2017 – 06/30/2022
Tracking neuro-cognitive changes during evidence-based reading instruction in typically and atypically developing children
Goal: To examine the neurocognitive bases of treatment response to a well-established evidence-based treatment program using MRI and functional near infrared spectroscopy (fNIRS).
BBRF Young Investigator Award (PI Keio U/Yamagata) 01/01/2017 – 12/31/2018
Brain and Behavioral Research Foundation
Female-specific intergenerational transmission patterns of the human corticolimbic circuitry in depression
Goal: To investigate correlation in resting-state connectivity in depressed mothers and their female/male offspring
BBRF Young Investigator Award (PI UCSF/Wang) 01/01/2017 – 12/31/2018
Brain and Behavioral Research Foundation
Preliminary investigation of the corticolimbic circuitry using a natural human cross-fostering design and resting-state fMRI
Goal: To compare correlation in resting-state fMRI connectivity between mother-daughter dyads in three groups of In Vitro Fertilization (IVF) families